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2003 Course Bio-Informatics (Elective I)

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Total No. of Questions :12] P1364 [Total No. of Pages :3 [3864]- 419 B.E. (I.T.) BIO-INFORMATICS ( 2003 Course) (Elective - I) Time : 3 Hours] [Max. Marks : 100 Instructions to the candidates: 1) From section I answerQ.1 or Q.2 , Q.3 or Q.4 ,Q.5 or Q.6 and answer Q.7 or Q.8, Q.9 or Q.10, Q.11 or Q.12 from section II. 2) Answer to the two sections should be wirtten in separate books. 3) Neat diagrams must be drawn wherever necessary. 4) Figures to the right indicate full marks. 5) Assume suitable data, if necessary. SECTION - I Q1) The probability of a patient having a particular genetic disease is 0.6. Calculate the pretest odds? If the Likelihood ratio is given as 2.75, calculate the posttest odds? Find the probability of the patient suffering from the genetic disease? Explain any two limitations of Bayes Theorem? [16] OR Q2) a) b) Explain Microarray Spotting Process Flow. [8] Explain the Gene Mapping Process in detail. [8] Q3) a) What is data mining? Mention the various tools used in Data Mining?[8] b) What is Clustering? Explain Hierarchical Clustering. Explain K-means clustering. [8] OR Q4) a) For the given fluorescence data as x[n] in the table below, calculate mean, standard deviation and variance? [8] n x[n] b) c) d) 1 2 3 4 5 6 7 2.2 8.6 3.4 13.3 52.7 1.3 4.8 Explain the concept of True Positives, True Negatives, False Positives and False Negatives? [4] Explain the concept of Sensitivity and Specificity along with the formulae. [2] Explain the concept of Receiver Operating Characteristics? [2] P.T.O. Q5) a) b) List different computational methods of sequence alignment and discuss any two in detail? [8] Explain the Central Dogma of Molecular Biology. [10] OR Q6) a) Explain following terms : i) Neural Networks. ii) b) [10] Hidden Markov Models. Explain Inductive Logic Programming and Deductive Logic Programming along with the differences between the two [8] SECTION - II Q7) What is an E-value? You do a databank search using FASTA with an amino acid sequence as a query. The only reported match has an E-value of 10. What does this mean for the similarity of the two sequences? [16] OR Q8) a) BLAST and FASTA are two widely used tools for sequence alignment. [8] Explain only the differences in their approaches? b) Discuss the applications of PSI-BLAST program exploring protein family relationships? [8] Q9) Explain in detail-FASTA algorithm for database search with an example. [16] OR Q10)a) What is Genetic Engineering? Explain Genetic Markers. What are the dangers of genetic engineering? [8] b) Explain the process of interchange and transformation of pollutant in atmosphere, hydrosphere and lithosphere. [8] [3864]-419 2 Q11)a) For the given two nucleotide sequences calculate the alignment score. Use gap penalty of (-0.5) per gap. Assuming opening cost and extension cost of (-0.5) each calculate the penalty gap, using this also calculate expanded gap penalty. [12] Sequence 1 : ATTCGGCATTCAGAGCTAGA. Sequence 2 : ATTCGACATT-----GCTAGTGGTA. b) Given A = [ 2 3 8 4 1 ] and B = [911 1 0 2 4 5 6 7 3 2], calculate Max Value = f(A1, Bi), where, i = 1, 2, ........,11 . [6] OR Q12)Explain the methods of protein structure prediction and determination : [18] a) Experimental. b) Ab-initio. c) Heuristic. zzzz [3864]-419 3

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