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2003 Course Pharmaceutical Biotechnology (Elective I)

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Total No. of Questions : 12] P1320 [Total No. of Pages : 2 [3864]-437 B.E. (Biotechnology) PHARMACEUTICAL BIOTECHNOLOGY (416281) (Sem . - I) (Elective - I) Time : 3 Hours] [Max. Marks : 100 Instructions to the candidates : 1) Answer three questions from Section I and three questions from Section II. 2) Answers to the two sections should be written in separate books. 3) Figures to the right indicate full marks. 4) Neat diagrams must be drawn wherever necessary. SECTION - I Q1) Q2) Q3) Q4) Q5) Q6) Classify various types of solid and liquid dosage forms. Write in detail about Solid dosage forms with suitable example. [18] OR What is pharmacokinetics? Explain principles of first-order kinetics along with mathematical equations and graphical representation. [18] Enlist different biopharmaceuticals drugs derived from plants. Explain in detail with any three examples. [16] OR Derive pharmacokinetic equations and explain in detail one compartment open model for intravenous infusion. [16] a) Write in detail about G protein coupled and Nuclear receptors. b) What is ADME profile of a drug? OR Write short notes (Any Four) : a) Mechanism of anti-infectives. b) Bioavailability. c) Drugs acting on CNS. d) Friability test. e) Parentrals. f) Target oriented drug delivery. g) Ligand gated Ion channels. [12] [4] [16] P.T.O. SECTION - II Q7) Q8) What are various strategies adopted for drug discovery process? Explain in detail any one technique. [18] OR What is In-silico drug discovery? Explain in detail the various steps involved in it. [18] Q9) a) Write in detail about Phase I and Phase II clinical trials. [12] b) Explain the terms NDE and IND. [4] OR Q10) a) Explain in detail various side effects and adverse effects induced by drugs. [12] b) What are antidotes? Explain with suitable example. [4] Q11) Write in detail about New drug application and Abbreviated New drug application. [16] OR Q12) Write short notes (Any Four) : [16] a) Allergic reaction to drugs. b) Teratogenesis. c) Indian Pharmacopoeia. d) FDA. e) Food, drug and cosmetic act. f) QSAR. g) Prototype drug. rrrr [3864]-437 -2-

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