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2003 Course Bioinformatics

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Total No. of Questions : 12] P957 [Total No. of Pages : 3 [3664]-352 B.E. (Information Technology) BIOINFORMATICS (2003 Course) Time : 3 Hours] [Max. Marks : 100 Instructions to the candidates : 1) Answer three questions from section I and three questions from Section II. 2) Answers to the two sections should be written in separate books. 3) Neat diagrams must be drawn wherever necessary. 4) Figures to the right indicate full marks. 5) Assume suitable data, if necessary. SECTION - I Q1) a) Define bioinformatics. Mention and explain its various applications.[9] b) Explain the major types of protein databases with most suitable example for each. [7] OR Q2) a) Explain how molecular biology is considered as an information science. Also explain central dogma of molecular biology with neat diagram.[8] b) What is genomics? Explain the difference between structural & functional genomics. State the tools & techniques included in both. [8] Q3) a) What is structure visualization? State & explain the various features of representative protein structure rendering programs and compare them.[9] b) Explain user interface and information theory. Also explain the four basic components in user interface hierarchy with neat diagram. [8] OR Q4) a) b) Describe the working of microarray with spotting technique. What are the sources of variability in spotting? Compare spotting and affimetrix microarray preparation process. [9] Explain various data mining methods with neat diagrams. [8] P.T.O.

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