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2003 Course Bio-Informatics (Elective I)

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Total No. of Questions :12] [Total No. of Pages : 3 P1570 [3764]-434 B.E. (I.T.) BIO - INFORMATICS (Elective - I) Time :3 Hours] [Max. Marks : 100 Instructions to the candidates: 1) Answer any three questions from each section. 2) Answers to the two sections should be written in separate books. 3) Neat diagrams must be drawn wherever necessary. 4) Assume suitable data, if necessary. SECTION - I Q1) a) b) Explain the Central Dogma of Molecular Biology. [8] Explain the Gene Mapping Process in detail. [8] OR Q2) a) Explain the odds-likelihood form of Bayes Theorem and explain any two limitations of Bayes Theorem? [8] b) The probability of a patient having a particular genetic disease is 0.5. calculate the pretest odds? If the Likelihood ratio is given as 2.75, calculate the post-test odds? Find the probability of the patient suffering from the genetic disease? [8] Q3) a) b) Explain Microarray Spotting Process Flow? [8] What is Clustering? Explain Hierarchical Clustering. Explain K-means clustering? [8] OR Q4) a) For the given fluorescence data as x[n] in the table below, calculate mean, standard deviation and variance? [8] n 1 2 3 4 5 6 7 x [n] 3.2 1.6 4.4 3.3 2.7 1.7 6.8 P.T.O.

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