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2003 Course Pharmaceutical Biotechnology (Elective I)

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Total No. of Questions : 10] P1597 [Total No. of Pages : 2 [3764]-457 B.E. (Biotechnology) PHARMACEUTICAL BIOTECHNOLOGY (2003 Course) (Elective - I) (416281) (Semester - I) Time : 3 Hours] [Max. Marks : 100 Instructions to the candidates: 1) 2) 3) 4) Answer three questions from Section I and three questions from Section II. Answers to the two sections should be written in separate answer books. Neat diagrams must be drawn wherever necessary. Figures to the right indicate full marks. SECTION - I Q1) Write in detail different routes of drug administration. Explain various types of dosage forms along with the example. [18] OR Q2) Explain in detail controlled and modified release dosage forms. [18] Q3) What is Kinetics of drug absorption? Explain the method of residual (feathering curve) and Wagner nelson method. [16] OR Q4) a) Explain the terms Bioavailability. Enlist methods of determination of bioavailability. [8] b) Write in detail factors affecting drug elimination. Q5) Write short notes. (Any Two 8 marks each) [8] [16] a) Mechanism of NSAIDs. b) Tablet Evaluation tests. c) Accelerated stability testing. d) Target oriented drug delivery system. P.T.O. SECTION - II Q6) Write in detail about acute and chronic toxicity. Add note on Toxicity testing. [18] OR Q7) Explain in detail various Phases involved in Clinical trials. [18] Q8) a) Write in detail about structure-activity relationship (SAR) and Quantitative SAR (QSAR). [12] b) Explain the Target-structure based drug discovery. [4] OR Q9) a) Explain in detail food, drug and cosmetic act. b) Write note on Allergic reaction to the drugs. Q10) Write short notes. (Any Two 8 marks each) a) IPR. b) ICH guidelines. c) In-silico drug discovery. d) Antidotes. [3764]-457 2 [12] [4] [16]

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