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2003 Course Bioinformatics & Regulations

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Total No. of Questions : 10] P1401 [Total No. of Pages :2 [3764] - 460 B.E. (Biotechnology) BIOINFORMATICS AND REGULATIONS (2003 Course) (Sem. - II) (416288) Time : 3 Hours] [Max. Marks:100 Instructions to the candidates: 1) Answer three questions from Section I and three questions from Section II. 2) Answers to the two sections should be written in separate answer books. 3) Neat diagrams should be drawn whenever necessary. 4) Figures to the right indicate full marks. SECTION - I Q1) Define databases. Classify protein databases. Write in detail about Secondary Protein databases. [18] OR Q2) Enlist Heuristic methods of sequence alignment. What is FASTA? Explain in detail about principal and working of FASTA. [18] Q3) Align the following two sequences using Needleman wunsch algorithm, and write the optimal alignment. [16] [Match +1, Mismatch - 1, Gap - 1] Seq. 1 GTAG Seq. 2 GAG OR Q4) Define Bioinformatics. Write in detail about scope, goal and applications of bioinformatics. [16] Q5) Write short notes [Any two] : a) Primary nucleotide databases. b) BLAST. c) SCOP & CATH. d) SGD & UNIGENE. [16] P.T.O.

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