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ICSE Class X Prelims 2025 : Biology (St. Xavier's Institution (SXI), Panihati, Kolkata)

4 pages, 22 questions, 0 questions with responses, 0 total responses,

Sharanya Mistry
St. Claret School, Debpukur, Sewli - Telinipara, Kolkata
ICSE Science

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vanced Molecular Biology an... v BIOTECH!'iOLOGY PAPER : SC/BT/231 T ( Advanced Molecular Biology and Genetics ) Full Marks: 40 Time : 2 Hours GROUP-A (25 Marks) Answer Question no. 1 and any four questions from the rest 1. Answer any jive questions from the following : I x5=5 (a) Does genome size correlate directly with organism complexities? Explain your reasoning. (b) ln which phase of the cell cycle, the DNA helicase is loaded on to the origin of replication in eukaryotes? (c) How does the function of poly (A) polymerase differ from RNA polymerase? (d) How do the mRNAs of eukaryotes differ from the mRNAs of prokaryotes? (e) What is mRNA editing? Provide an example. /Tum Over/ BIOTECH-818 Adva nced Mole cula r Biology an... " ([J 2 of 7 (2 ) How do 'FSE's and 'ESl's contribut splicing in higher eukaryotes? e to alternative (g) Which protein binds to the insulator' eleme n ntto execute its act1v1ty t (h) Which one among the following the DNA b. d. ' - m tng' 'activa~ion' _domains of a eukaryotic activator display0 : more d1vers1ty and less conservation? (i) What do you mean by LCR? Provide an example of gene cluste r in human, which is controlled by LCR. (j) Which specif ic amino-acid residues in the c-tenninal domain (CTD ) of eukaryotic RNA polymerases play crucial role in the cross-talking between various mRNA processing events ? [COl, CO2, C04) (a) lnterg enic seque nces make up to the 60% of the human genom e. Were do these interg enic sequences come . fi 3 from and what are some of their unctions ? (b) Name the types of bonds that occur between histone . fDNA where these proteins and DNA and the region fie? . quence -spect bonds form. Are these interactions se 2 Explain. Why or why not? (COll HOT ECH -818 I contini,ed 1 vanced Molecular Biology an... v ([] 3 of 7 (3 ) 3. (a) Which pro_te~n domain(s_) recogniz.e the acetylated lysine and/or argmme present m histone amino-terminal tails? Which protein domain(s) recognize methylated histone amino-terminal tails? 2 (h) With a suitable diagram, briefly describe different components of a nuclesome. 3 [CO2, CO4] 4. (a) What is the role of Pol lJ CTD phosphorylation in the regulation ofdifferent phases of euk.aryotic transcription and mRNA processing? 3 (b) Why is the Mediator Complex only required for transcription in vivo, but is dispensable in vitro? What is different about the DNA template for transcription in vivo compared to the templates used in in vitro transcription systems? 2 [CO2, CO4] 5. (a) Typically, how many transcription factors participate in eukaryotic transcription? What is the major functional role played by these general transcription factors? (h) "Despite being a sequence specific DNA binding protein, TATA-Binding Protein (TBP) binds to the minor groove of the target DNA" -justify the statement. 2 1co2, CO-'I BIOTECH-818 /Tum Over/ Advanced Mo le c u la r B io lo fiD 6. (a J rbJ g y an... v 4 of 7 l4 l O ra \, th e re a c ta . . n ts and the products o f a spl med1atcd sph.cm g. reaction. indic 1ceosomeating the s "p the 3' splice site. l -~ ICC <; 1tc th e branch site an d th e poly-pyrimidin~ tract. ln c lu d c th e c o n se n su s seq uences at the vari si te s in y o u r d ra ouc; w in g . Draw the st ru ct ure o f adenosine p re se n t at th e b ra n c h si te o f a la riat and indicate b o n d s th a t c o n n e the c t it to its immed ia te S ' an d 3' neighbors a s w e ll as to th e g u a n in e a t the S ' end o f the intro n. 3 W h ic h e n z y m e s a re e ss e n ti a l for the capping proce a t th e S '- e n d o f th ss e tr a n sc ri b in g m R N A s in eukaryotes? lf th e c a p p in g p ro c e ss fails to ta k e place properly, w w il l b e th e e x p e hat c te d c o n se q u e n c e in th e el o ngation o f tr~~~~ 2 lC 0 3 , C 0 3 \ 7. (a ) 8. (U ) W it h a si m p le sk e tc h , su m m a ri z e th e cleavage p o ly a d e n y la ti o n and process. beginnin g wi~h an_ RNA that b e in g e lo n g a te d i~ p a st the p o ly a d e n y la u o n s1te. ., What is Exon-D efinition''? H o w is the concept o f .. D e fi n it io n " u ti li ~xon z e d by th e c e ll s to decide th a t~ g~ve e x o n will b e in c ~ lu d e d in the fina l mature transcnp t. tC 0 3 , CO~\ .) l W h a t is .. E n d -R e p li.c a ti.o n P ro b e m ,. in \!ukaryot~s. . Explain with a su . ... \\s . d itable diagram . How O eu kar)'Ol\C 1.:.. re so lv e th is p ro b 2 le m ? B lO T E C H -8 1 8 I Continued I

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