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Pune University - Pharmaceutical Microbiology, April 2010 (Old Course)

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Total No. of Questions : 5] [Total No. of Pages : 2 P1004 [3725] - 42 M.Sc. MICROBIOLOGY MB - 802 : Pharmaceutical Microbiology (2005 Pattern) Time : 3 Hours] [Max. Marks : 80 Instructions to the candidates: 1) All questions are compulsory. 2) Figures to the right indicate full marks. 3) Draw diagrams wherever necessary. 4) All questions carry equal marks. 5) Use of the logarithmic electronic pocket calculator is allowed. 6) Assume suitable data, if necessary. Q1) Answer any one of the following : a) Explain the in vitro and in vivo evaluation of a drug. b) Explain the role of bioinformatics in the study of a drug. [16] Q2) Answer any two of the following : a) Write in brief about the phases of clinical trials for a drug. b) What is the role of cheminformatics in the study of a drug? c) Enlist FDA guidelines for evaluation of drug. [16] Q3) Answer any two of the following : [16] a) How do the drugs interfere in the protein synthesis? Give the probable reasons for the resistance developed in the cells. b) How will you assay an antimicrobial in agar medium? c) Explain briefly about the toxicity and allergy testing for new antibiotics. P.T.O. Q4) Write short notes on (any four) : a) Action of fusidic acid. b) Nitrofurans. c) Anti-viral agents. d) Tolerability testing. e) [16] Adhesins. Q5) Extract of aloe vera showed an excellent zone of inhibition against clinical strains of Staphycoccus aureus. What will be your steps to assess this extract before you actually try on human beings? Explain in detail. [16] vvvv [3725]-42 2

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Additional Info : M.Sc. MICROBIOLOGY, MB - 802 : Pharmaceutical Microbiology (2005 Pattern), Pune University
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