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Pune University - Immunology, April 2010 (Old Course)

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Total No. of Questions : 5] P1000 [Total No. of Pages : 2 [3725] - 31 M.Sc. MICROBIOLOGY MB - 701 : Immunology (2005 Pattern) Time : 3 Hours] [Max. Marks : 80 Instructions to the candidates: 1) All questions are compulsory. 2) All questions carry equal marks. 3) Neat well labeled diagrams must be drawn wherever necessary. 4) Use of log tables and electronic pocket calculators is allowed. 5) Assume suitable data if necessary. Q1) Attempt any one of the following: [16] a) Describe polymorphism in Class I & Class II MHC molecules. b) Enlist the key cells that may kill tumor cells. How do they destroy tumor cells? Describe the central role of interferon in regulating tumor cell killing. c) Explain the kinetics of antigen antibody reactions. Q2) Attempt any two of the following : [16] a) Explain why individuals with phagocytic disorders frequently suffer from bacterial infections. b) Describe the occurrence of various immune system components in Invertebrates. c) Explain the regulation of classical complement pathway. Q3) Attempt any two of the following : [16] a) Describe the major immune-regulatory cells of our body. Explain their role in immunoregulation. b) Explain the signal transduction by TCR : CD 3 complex. c) Describe the role of BRMs. P.T.O. Q4) Write short notes on any four of the following : a) SLE. b) Alfa fetoprotein. c) Mechanism of tolerance induction. d) Western blotting. e) Animal models for autoimmunity. [16] Q5) Given below is the actuarial curve showing survival times of skin grafts between mice mismatched at the MHC and treated with anti-CD8 antibody or anti-CD4 antibody or a combination of both antibodies. [16] a) Give the mechanism of allograft rejection. b) Explain the role of CD4 and or CD8 cells in rejection of allograft. c) How allograft rejection is prevented? vvvv [3725]-31 2

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Additional Info : M.Sc. MICROBIOLOGY, MB - 701 : Immunology (2005 Pattern), Pune University
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