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Pune University - Immunology, April 2010

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Total No. of Questions : 5] [Total No. of Pages : 3 P1012 [3725] - 301 M.Sc. MICROBIOLOGY MB - 701 : Immunology (2008 Pattern) Time : 3 Hours] [Max. Marks : 80 Instructions to the candidates: 1) All questions are compulsory. 2) All questions carry equal marks. 3) Neat well labeled diagrams must be drawn wherever necessary. 4) Use of log tables and electronic pocket calculator is allowed. 5) Assume suitable data, if necessary. Q1) Attempt any two of the following : a) Explain various methods to detect humoral deficiencies. b) Explain the immune mechanism to intracellular infections. c) [16] Describe the host immune response to tumors. Q2) Attempt any two of the following : a) Describe the mechanisms of tolerance induction. b) Comment on diversity of TCR. c) [16] Discuss status of immune system components in vertebrates. Q3) Attempt any two of the following : [16] a) Explain use of inbred animals in immunology research. b) Describe the regulation of classical pathway of complement activation. c) Describe in detail the pathophysiology of Asthma. P.T.O. Q4) Write short notes on any four of the following : a) Hemolytic plaque assay. b) Hodgkin s disease. c) General properties of cytokines. d) SLE. e) [16] Diagnosis of herpes virus infection. Q5) A study was carried out to evaluate the potential of circulating immune complexes (CIC) as marker for disease progress in oral cancer. The study included : a) [16] 60 patients (36 males and 24 females) with primary oral squamous cell carcinoma of the buccal mucosa, ranging in age from 30 to 75 years (median age 52.5 years). Histopathologically the tumors were categorized as : well differentiated squamous cell carcinoma (WDSCC), moderately differentiated squamous cell carcinoma (MDSCC) and poorly differentiated squamous cell carcinoma (PDSCC); with 20 cases in each category. b) Patients with precancerous lesions : premalignant lesions consisting 20 oral leukoplakias (OL) (12 males and 8 females) and 20 oral submucous fibrosis (OSMF) (13 males and 7 females) ranging in age from 23 to 60 years (median age 41.5 years). c) Normal subjects : 40 normal subjects (22 males and 18 females) ranging in age from 25 to 60, who were not having any major illness in the past. Circulating immune complexes were separated by PEG-mediated precipitation technique and developed turbidity was quantitated spectrophotometrically. The levels of CIC as turbidity values at 450 nm in different subjects are : [3725]-301 2 Subjects Number of samples Range Mean SD SE % positive samples Normal 40 0.010-0.046 0.02315 0.013461 0.00246 - OL 20 0.013-0.085 0.03817 0.016808 0.00376 15 OSMF 20 0.045-0.253 0.1871 0.054718 0.0173 90 WDSCC 20 0.040-0.153 0.08912 0.032887 0.00735 92 MDSCC 20 0.100-0.162 0.1129 0.016603 0.00371 100 PDSCC 20 0.150-0.435 0.3051 0.090199 0.0202 100 Analyze the data using convenient statistical tools and discuss the pros and cons of CIC as prognostic tool in oral cancer. vvvv [3725]-301 3

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Additional Info : M.Sc. MICROBIOLOGY, MB - 701 : Immunology (2008 Pattern), Pune University
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