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Pune University - Pharmaceutical and Medical Microbiology, April 2010

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Total No. of Questions : 5] [Total No. of Pages : 2 P1015 [3725] - 401 M.Sc. MICROBIOLOGY MB - 801 : Pharmaceutical and Medical Microbiology (2008 Pattern) Time : 3 Hours] [Max. Marks : 80 Instructions to the candidates: 1) All questions are compulsory. 2) Figures to the right indicates full marks. 3) Draw diagrams wherever necessary. 4) All questions carry equal marks. 5) Use of the logarithmic electronic pocket calculator is allowed. 6) Assume suitable data, if necessary. Q1) Answer any one of the following : [16] a) Explain the various phases involved in discovery of a drug. b) Illustrate the bioassay technique of antibacterial agents as per CLSI guidelines and factors affecting the same. Q2) Answer any two of the following : [16] a) Explain the safety profile assessment of drugs. b) Brief the mechanisms involved in invasion and adhesion of a virulent bacteria. c) Explain the validation criteria for biologicals. Q3) Answer any two of the following : [16] a) Describe the mechanism of bacterial resistance to host cellular defenses. b) With suitable example discuss the mode of actions of endotoxin. c) Explain the carcinogenicity testing of drugs. P.T.O. Q4) Write short notes on (any four) : a) LD 50. b) Mutagenicity testing. c) FDA guidelines for drugs. d) Pharmacokinetics. e) Antimycobacterial testing. [16] Q5) The table below shows in vitro susceptibility of clinical mold isolates to itraconazole as determined by the microdilution technique Species (No. of species) MIC ( g/ml) Range 50% 90% >8 >8 >8 A.flavus (10) 0.25-1 0.25 1 A.fumigatus (12) 0.5-1 1 1 Fusarium spp. (13) a) Comment on the scientific data given above with respect to inhibition of Fusarium sp. and Aspergillus sp. by itraconazole. [8] b) c) How do azoles act in human cells? Define MIC, MBC and IC50. vvvv [3725]-401 2 [4] [4]

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Additional Info : M.Sc. MICROBIOLOGY, MB - 801 : Pharmaceutical and Medical Microbiology (2008 Pattern), Pune University
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