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Pune University - Sem - II : Bioinformatics, April 2010

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Total No. of Questions :8] [Total No. of Pages : 2 P1200 [3727-B]-602 M.Sc. BIOTECHNOLOGY BT 22 : Bioinformatics (2008 Pattern) (New) (Sem. - II) Time :3 Hours] [Max. Marks : 80 Instructions to the candidates: 1) Attempt a total of five questions selecting at least two questions from each section. 2) Answers to the sections must be written on separate answer books. 3) Neat diagrams must be drawn wherever necessary. 4) Figures to the right indicate full marks. SECTION - I Q1) What is bioinformatics? Elaborate on the concept of bioinformatics. Mention the tools of bioinformatics and enlist its applications. [16] Q2) a) b) Mention the publicly available databases. Explain any one of them in detail. [8] Explain in brief the methods of visualisation of data. [8] Q3) What is homology search? Mention the steps involved in homology search. Explain the procedure with the help of an appropriate example. [16] Q4) Write notes on any two of the following : a) Gene expression informatics. b) Parabolic interpolation. c) [16] Structure based drug designing. SECTION - II Q5) a) How are molecular interactions simulated? Explain with the help of suitable example. [8] b) How are binding sites in protein located? Explain with the help of an appropriate example. [8] P.T.O. Q6) How are protein structures predicted? Add an explanatory note on classification of protein structures. [16] Q7) Explain the following : a) b) [16] Ramachandran plot Protein folding -structure function relationship. Q8) Write notes on any two of the following. a) Bioinformatics business models. b) Computer based research. c) Role of bioinformatics in drug designing. #### [3727-B]-602 2 [16]

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Additional Info : MSc BIOTECHNOLOGY, BT 22 : Bioinformatics (2008 Pattern) (New Course) (Semister - II), Pune University
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