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GCE JAN 2009 : (AS 1) Cell Biology

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Centre Number 71 Candidate Number ADVANCED SUBSIDIARY (AS) General Certificate of Education January 2009 Biology assessing Module 1: Cell Biology ASB11 Assessment Unit AS 1 [ASB11] WEDNESDAY 14 JANUARY, AFTERNOON TIME 1 hour. INSTRUCTIONS TO CANDIDATES Write your Centre Number and Candidate Number in the spaces provided at the top of this page. Write your answers in the spaces provided in this question paper. Answer all eight questions. You are provided with Photograph 1.3 for use with Question 3 in this paper. Do not write your answers on this photograph. For Examiner s use only Question Number 1 INFORMATION FOR CANDIDATES The total mark for this paper is 55. Section A carries 43 marks. Section B carries 12 marks. You should spend approximately 15 minutes on Section B. You are expected to answer Section B in continuous prose. Quality of written communication will be assessed in Section B. Figures in brackets printed down the right-hand side of pages indicate the marks awarded to each question or part question. 2 3 4 5 6 7 8 Total Marks 3904 Marks BLANK PAGE 3904 2 [Turn over Section A Examiner Only Marks 1 Remark Read the following passage on bulk transport across the cell-surface membrane and write the most appropriate word in the blank spaces to complete the account. Bulk transport of molecules and particles may take place across the cellsurface membrane. Where this movement is out of the cell, it is called ______________________. Where this movement is into the cell, it is called ______________________. The invagination of a cell-surface membrane to ingest particles and form a vacuole is known as ______________________, whereas the invagination of the membrane to ingest liquids and form a vesicle is known as ______________________. [3] 3904 3 [Turn over 2 The diagram below shows the amino acids of the two polypeptides of human insulin. S A chain S asp-cys-tyr-asp-glu-leu-glu-tyr-leu-ser-cys-val-ser-ala-cys-cys-glu-glu-val-ile-gly S B chain S S S ala-lys-pro-thr-tyr-phe-phe-gly-arg-glu-gly-cys-val-leu-tyr-leu-ala-glu-val-leu-his-ser-gly-cys-leu-his-glu-asn-val-phe Reproduced with the permission of Nelson Thornes Ltd from Nelson Advance Science 3rd Ed - Molecules and Cells -John Adds, Erica Larkcom, Ruth Miller and Martin Furness-Smith - ISBN 978 0 7487 7484 5 first published in 2003 Examiner Only (a) How many bases on a messenger RNA molecule would code for the production of the A chain shown above? Marks Remark _______________________________________________________ [1] (b) Explain the role of the sulphur-containing amino acid, cysteine (cys), in the formation of the tertiary and quaternary structure of the insulin molecule. _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________ _______________________________________________________ [4] (c) In which part of the cysteine molecule would you expect to find sulphur? _______________________________________________________ [1] 3904 4 [Turn over 3 Photographs 1.3 A to D show light micrographs of bluebell cells at different stages of mitosis. Examiner Only Marks Remark (a) Identify the stage of mitosis shown by each of the cells A to D. A _______________________________________________________ B _______________________________________________________ C _______________________________________________________ D _____________________________________________________ [4] (b) Arrange the letters A to D to give the correct sequence of stages during mitosis. _______________________________________________________ [1] 3904 5 [Turn over 4 The diagram below summarises the processes involved in protein synthesis. Examiner Only Marks Remark A B C Nucleus messenger RNA Source: Adapted from Life Sciences on File, Elaine Broodbridge, Ruth Swan, 1986. (a) Identify the structures labelled A to C. A _______________________________________________________ B _______________________________________________________ C _____________________________________________________ [3] 3904 6 [Turn over (b) Describe how messenger RNA is formed from DNA. Examiner Only Marks Remark _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________ _______________________________________________________ [4] 3904 7 [Turn over 5 The enzyme amylase catalyses the following reaction. Examiner Only Marks Starch Remark > maltose (a) Starch and maltose are both carbohydrates. (i) Describe how they are similar in their molecular structure. _________________________________________________________ _______________________________________________________ [1] (ii) Describe how they differ in their molecular structure. _________________________________________________________ _________________________________________________________ _______________________________________________________ [2] (b) In an investigation of the above reaction, 0.1% amylase was added to a 1% solution of starch. The amount of starch remaining in solution was determined over time. The results are shown in the table below. Time/minutes Amount of starch remaining in solution/% 0 1.0 0.5 0.5 1.0 0.25 2.0 0.07 3.0 0.02 4.0 0.01 (i) Describe the pattern of change in the amount of starch remaining in solution over time. _____________________________________________________ _____________________________________________________ _____________________________________________________ ___________________________________________________ [2] 3904 8 [Turn over (ii) Explain the changes in the amount of starch remaining in solution over time. Examiner Only Marks Remark _____________________________________________________ _____________________________________________________ _____________________________________________________ ___________________________________________________ [2] 3904 9 [Turn over 6 Cylinders of potato tissue were immersed in sucrose solutions, differing in their solute potential, for 24 hours and the percentage change in length determined. The results are shown in the graph below. 10 8 4 2 Solute potential/kPa 0 2000 1600 1200 800 400 2 4 Percentage change in length/% 6 6 8 10 (a) With reference to water potential, explain the change in length that occurred when the cylinder of potato tissue was immersed in a sucrose solution of solute potential 600 kPa. Examiner Only Marks Remark _________________________________________________________ _________________________________________________________ _________________________________________________________ _______________________________________________________ [2] (b) Using the information in the graph, determine the water potential of the potato tissue. _________________________________________________________ Explain your reasoning. _________________________________________________________ _______________________________________________________ [2] 3904 10 [Turn over (c) The initial length of the potato cylinder immersed in a solution of water potential 1600 kPa was 50 mm. Calculate its final length. (Show your working in the space below.) Examiner Only Marks Remark Answer _________________[2] (d) Draw a potato cell as it might appear when immersed (for 24 hours) in a sucrose solution of solute potential 1200 kPa. [1] 3904 11 [Turn over 7 The diagram below shows the pBr322 plasmid (found in the bacterium, E. coli) with an enlarged view of the site at which the restriction enzyme Sal1 cuts open the plasmid. This plasmid carries antibiotic resistance genes for ampicillin (Ampr) and tetracycline (Tetr). Remark GT Tetr TG AC GC CG CA Ampr Examiner Only Marks Sal1 restriction site of Sal1 which cuts nucleic acid between the bases indicated ( ) (a) Explain why plasmids are described as extrachromosomal DNA in bacteria. _________________________________________________________ _______________________________________________________ [1] (b) Describe how foreign DNA could be incorporated into the pBr322 plasmid using the restriction enzyme Sal1. _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________ _______________________________________________________ [3] 3904 12 [Turn over (c) Describe how host bacteria may be induced to take up modified pBr322 plasmids. Examiner Only Marks Remark _________________________________________________________ _______________________________________________________ [1] (d) Explain how bacteria which had taken up the modified pBr322 plasmid might be identified from those bacteria which had failed to take up plasmids or had taken up the unmodified plasmid. _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________ _______________________________________________________ [3] 3904 13 [Turn over Section B Examiner Only Marks Remark In this section you are expected to answer in continuous prose, supported, where appropriate, by diagrams. You are reminded that up to two marks in this question are awarded for the quality of written communication. [2] 8 Give an account of the structure and function of the following cell organelles. Golgi apparatus Mitochondrion Chloroplast [10] Golgi apparatus _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ Mitochondrion _____________________________________________________________ _____________________________________________________________ 3904 14 [Turn over Examiner Only _____________________________________________________________ Marks Remark _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ Chloroplast _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ 3904 15 [Turn over Permission to reproduce all copyright material has been applied for. In some cases, efforts to contact copyright holders may have been unsuccessful and CCEA will be happy to rectify any omissions of acknowledgement in future if notified. 935-008-1 3904 16 [Turn over [Turn over ASB1S9 D C 3904 B Photographs 1.3 A to D (for use with Question 3) A GCE Biology Advanced Subsidiary (AS) Assessment Unit AS 1 Module 1: Cell Biology January 2009 ASB11IN1 Source: Pr. G. Gimenez-Martin/Science Photo Library

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Additional Info : Gce Biology January 2009 Assessment Unit AS 1 Module 1: Cell Biology
Tags : General Certificate of Education, A Level and AS Level, uk, council for the curriculum examinations and assessment, gce exam papers, gce a level and as level exam papers , gce past questions and answer, gce past question papers, ccea gce past papers, gce ccea past papers

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